柠檬苦素在大鼠体内的排泄途径分析

刘史佳; 冯丽雯; 戴国梁; 黄国栋; 孙冰婷; 居文政

doi:10.13422/j.cnki.syfjx.2017010091

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柠檬苦素在大鼠体内的排泄途径分析

药物代谢 | 更新时间：2024-01-04

- 柠檬苦素在大鼠体内的排泄途径分析
- Excretion Pathway Analysis of Limonin in Rats
- 中国实验方剂学杂志 2017年23卷第1期页码：91-94
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81403174，81470197）;江苏省自然基金面上项目（BK20151602，BK20161610）
- DOI：10.13422/j.cnki.syfjx.2017010091
  中图分类号： R285.5
- 纸质出版日期：2017
- 稿件说明：
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刘史佳, 冯丽雯, 戴国梁, 等. 柠檬苦素在大鼠体内的排泄途径分析[J]. 中国实验方剂学杂志, 2017,23(1):91-94.

LIU Shi-jia, FENG Li-wen, DAI Guo-liang, et al. Excretion Pathway Analysis of Limonin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 91-94.
刘史佳, 冯丽雯, 戴国梁, 等. 柠檬苦素在大鼠体内的排泄途径分析[J]. 中国实验方剂学杂志, 2017,23(1):91-94. DOI： 10.13422/j.cnki.syfjx.2017010091.

LIU Shi-jia, FENG Li-wen, DAI Guo-liang, et al. Excretion Pathway Analysis of Limonin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(1): 91-94. DOI： 10.13422/j.cnki.syfjx.2017010091.

摘要

目的：考察柠檬苦素在大鼠体内的代谢途径，为阐明该药物的作用机制提供参考。方法：大鼠按80 mg·kg-1灌胃给予柠檬苦素，收集胆汁、尿液和粪便，利用HPLC和LC-MS/MS测定大鼠胆汁、尿液和粪便中柠檬苦素的含量，计算其累积排泄量和累积排泄分数。结果：柠檬苦素在大鼠粪便、尿液和胆汁中的累积排泄分数合计约50%，只有近一半的药物以原型形式排泄出体外。原药从尿液和胆汁中的总排泄量<1%，大部分以原型药物通过粪便排出。结论：柠檬苦素在大鼠体内的主要排泄途径为粪便，少量药物吸收进入血液后通过肝脏代谢，少量药物通过尿液排出体外。

Abstract

Objective: To investigate metabolic pathway of limonin in rats and its mechanism. Method: Bile

urine and feces of rats were collected after oral administration of limonin with dose of 80 mg·kg-1.HPLC and LC-MS/MS were used to determine the concentration of limonin in bile

urine and feces of rats

then calculated the cumulative excretion and cumulative fractional excretion. Result: Total cumulative fractional excretion of limonin in feces

urine and bile was about 50%

only about half of the drug was excreted in the form of prototype.Limonin excreted from the urine and bile was less than 1%.Most of limonin excluded through feces with prototype. Conclusion: Feces is major excretion pathway of limonin in rats after oral administration

only a small portion of the drug is absorbed into rat plasma.

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