Objective: To observe the effect of Taohong Siwutang (TST) on the contents of endothelin-1 (ET-1)

angiopoietin-1 (Ang-1) and vascular endothelial growth factor (VEGF) in serum of cerebral ischemia rats. Method: Models of cerebral ischemia were reproduced with 48 healthy SD rats through middle cerebral artery occlusion (MACO). All rats were divided into six groups:sham group

model group

Taohong Siwu decoction groups (18

9

4.5 g·kg-1) and nimodipine group (0.02 g·kg-1). After the successive oral administration for 7 days

the volume of cerebral infarction was detected by TTC staining method; And whole blood viscosity and plasma viscosity were tested to observe the effects of TST on the hemorheology of rats with cerebral ischemia injury; And the content of serum ET-1

Ang-1 and VEGF were detected by ELISA. Result: The high dose group of TST could significantly reduce cerebral infarction volume. Compared with the sham group

whole blood viscosity and plasma viscosity of rats in model group were significantly increased

with no statistical significance. Compared with the model group

high and medium-dose TST treatment groups showed significant decreases in whole blood viscosity and plasma viscosity. Meanwhile

the low-dose TST treatment group showed significant decrease in the plasma viscosity in comparison with model group. Compared with the model group

TST remarkably reduced the levels of ET-1 in serum

and increased the levels of Ang-1

VEGF in serum. Conclusion: TST has the effect in markedly improving cerebral infarction volume

and promoting angiogenesis in cerebral ischemia rats. Its mechanism may be related to the regulation of content of ET-1

Ang-1 and VEGF in serum.