Objective: To apply TCMISS (V2.5) to analyze the composition principles of formula containing Shengmaisan in Dictionary of Chinese Medicine Prescription (Ginseng Radix et Rhizoma

Ophiopogonis Radix

Schisandrae Chinensis Fructus) and provide a basis for clinical medication and new drug research and development. Method: Formulas containing Ginseng Radix et Rhizoma

Ophiopogonis Radix and Schisandrae Chinensis Fructus in Dictionary of Chinese Medicine Prescription were collected

sorted and entered TCMISS to build a database and analyze their medication rules and major indications. Result: The database records a total of 415 formulas

25 core drug compositions and 25 TCM compatible with Shengmaisan and selects blood drug ‘Angelicae Sinensis Radix’

Qi drug ‘Astragali Radix’

Yin drug ‘Cornt Fructus’ and Yang drug ‘Aconiti Lateralis Radix Praeparaia’ to analyze drug compositions. It is suggested that although changes in formulas containing Shengmaisan are complex

generally they still give priority to tonifying Qi and Yin. As compatibility changes

the characteristics of treatment differ. Conclusion: Dictionary of Chinese Medicine Prescription has a wide range of compatible drugs for Shengmaisan. The characteristics of treatment are clear. Most of them are tonic and beneficiary. Composition principles reflect the composition features of Shengmaisan when treating different diseases. They have a guiding significance for modern clinical application and provide a basis for modern inheritance and development of formulas containing Shengmai San.