Objective: To explore the traditional Chinese medicine (TCM) regularities and molecular mechanism for treating different diseases with same method on hyperuricemia (HU) and non-alcoholic fatty liver disease (NAFLD). Method: The regularities of TCM syndrome and Chinese herbs on HU and NAFLD were mined out by text mining and were visualized. Then the common TCM syndromes of HU and NAFLD and their corresponding Chinese herbs compatibility compound (CHCC) were extracted and obtained. Human target proteins corresponding to active ingredients and relevant genes of the above diseases were retrieved. Then the proteins and genes were imported into molecular network analysis platform respectively to build the corresponding networks. By network mapping analysis

some pathways and high link molecules in CHCC for treating HU and NAFLD could be found. Result: Phlegm and blood stasis block syndrome was the most common TCM syndrome for HU and NAFLD. Chinese herbs in CHCC (Saloiae Miltiorrhizoma Radix et Rhizoma

Rhei Radix et Rhizoma)

Poria

Alismatis Rhizoma

Angelicae Sinensis Radix

Atractybdis Macrocephalae Rhizoma were the most common herbs for the above two diseases. CHCC played a synergistic treatment effect on HU and NAFLD by regulating 5 molecules (26 S Proteasome

ERK1/2

NF-κB

UBC and Akt) and LXR/RXR activation pathway. Conclusion: HU and NAFLD had the biological foundation for treating different diseases with the same method. Text mining and molecular biological information network analysis were the effective methods for exploring the biological foundation.