GC-MS研究含天然麝香小金丸与含人工麝香小金丸特征化学成分

袁绿益; 陈娟; 常颜; 唐晓莹; Brian McGarvey; 王晓玲

doi:10.13422/j.cnki.syfjx.2017020043

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GC-MS研究含天然麝香小金丸与含人工麝香小金丸特征化学成分

化学与分析 | 更新时间：2024-01-04

- GC-MS研究含天然麝香小金丸与含人工麝香小金丸特征化学成分
- GC-MS Study on Characteristics of Xiaojin Pills Containing Natural Musk and Artificial Musk
- 中国实验方剂学杂志 2017年23卷第2期页码：43-47
- 作者机构：
- 作者简介：
- 基金信息：
  
  四川省科技厅科技支撑项目（2015SZ0040）;西南民族大学研究生创新科研项目（CX2015SZ044）
- DOI：10.13422/j.cnki.syfjx.2017020043
  中图分类号： O657.63;R286.0
- 纸质出版日期：2017
- 稿件说明：
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袁绿益, 陈娟, 常颜, 等. GC-MS研究含天然麝香小金丸与含人工麝香小金丸特征化学成分[J]. 中国实验方剂学杂志, 2017,23(2):43-47.

YUAN LYu-yi, CHEN Juan, CHANG Yan, et al. GC-MS Study on Characteristics of Xiaojin Pills Containing Natural Musk and Artificial Musk[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(2): 43-47.
袁绿益, 陈娟, 常颜, 等. GC-MS研究含天然麝香小金丸与含人工麝香小金丸特征化学成分[J]. 中国实验方剂学杂志, 2017,23(2):43-47. DOI： 10.13422/j.cnki.syfjx.2017020043.

YUAN LYu-yi, CHEN Juan, CHANG Yan, et al. GC-MS Study on Characteristics of Xiaojin Pills Containing Natural Musk and Artificial Musk[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(2): 43-47. DOI： 10.13422/j.cnki.syfjx.2017020043.

摘要

目的：建立GC-MS法分析小金丸中的特征成分。方法：采用无水乙醇超声提取小金丸中的挥发性成分，再采用气相色谱-质谱联用技术和自动质谱解卷积定性系统（AMDIS）对其特征成分进行定性分析。结果：共鉴定出53个化学成分，含天然麝香小金丸中鉴定出30个化合物，而含人工麝香小金丸中鉴定出23个化合物。含天然麝香小金丸中检测出7个特征成分，分别是棕榈酸乙酯；乙酸脱氢异雄甾酮；3-乙基-3-羟基-雄甾烷-17-酮；去氢表雄酮；雄甾酮；3，17-二酮雄甾烷；3，17-二醇雄甾烷，其相对质量分数分别为0.11%，1.12%，2.80%，1.59%，0.56%，1.99%，1.22%。特征成分中的甾体类化合物来自于天然麝香，酯类化合物可能是天然麝香中的某些化合物与其他药物配伍反应生成的物质。结论：该方法特征性强、方法简便、重复性好，为区分含天然麝香小金丸和含人工麝香小金丸提供参考依据。

Abstract

Objective: To establish the GC-MS analysis method for the identification of Xiaojin pills. Method: The volatile compounds in Xiaojin pills were extracted by ethanol

whose chemical constituents were then analyzed by gas chromatography-mass spectrum (GC-MS) and AMDIS. Result: A total of 53 compounds were identified

30 compounds were identified from Xiaojin pills containing natural moschus

23 compounds were identified from Xiaojin pills containing artificial musk. There are 7 characteristic compounds from Xiaojin pills containing natural musk

including palmitic acid ethyl ester

dehydroisoandrosterone 3-acetate

3-ethyl-3-hydroxy-androstan-17-one

dehydroepiandrosterone

androsterone

androstan-3

17-dione

androstane-3

17-diol

their relative contents were 0.11%

1.12%

2.80%

1.59%

0.56%

1.99%and 1.22%. The steroidal compounds in the characteristic compounds are derived from natural musk

and the ester compound may be a substance produced by the compatibility of some compounds of natural musk with other drugs. Conclusion: This method is characteristic

simple and reproducible

which provides a reference for the distinction Xiaojin pills containing natural-musk and artificial-musk.

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