LI Qin, HU Ji-hong, GAO Bo, et al. Advances on Immunoregulation Effect of Astragalus Polysaccharides[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(2): 199-206.
LI Qin, HU Ji-hong, GAO Bo, et al. Advances on Immunoregulation Effect of Astragalus Polysaccharides[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(2): 199-206. DOI: 10.13422/j.cnki.syfjx.2017020199.
Astragali Radix is a Chinese herbal medicine which is used for both medicine and food. astragalus polysaccharide (APS) is the highest bioactive component. APS has multiple effects
especially in recent years
immune regulation as a research focus. A large number of studies have shown that APS in vivo and in vitro have significant immune regulation
not only on the immunosuppressed animal model has a significant role
but also enhance the immune function of normal animals. At present
the research on APS is mostly confined to its own structure. It is widely used as immune adjuvant and animal feed additive. Its application scope is narrow and lacks deep excavation and scientific research. In recent years
the research of APS immunoregulation has been broadened
and its structure has been modified by different modification methods. The effect mechanism and the dose-effect relationship of various modified products on immune function have been studied. Tumor immunity
anti-virus immunity and immune-related gene regulation and so made a useful exploration. The effects of APS on organ immunity
cellular immunity
cytokines and intracellular messengers
tumor immunity
antiviral immunity
APS immunoreactivity and APS regulation on immune-related genes were summarized. 7 areas of the latest research results. In the future
we should strengthen the separation and purification of low molecular weight APS and APS structure characteristics and immune regulation of the structure-activity relationship and the role of target research
combined with chemical modification of APS regulation of the body's immune mechanism
to enhance its effective intake of the body to enhance the effect of immunity
to strengthen the potential of APS as a human immune adjuvant to promote its clinical application
the application of astragalus polysaccharides from the present to the veterinary animal husbandry and gradually broaden to the medical treatment.