Objective: To observe the effects of total extract from persimmon parasitism (EPP) in diabetic mice induced by streptozotocin (STZ). Method: EPP was extracted and diabetic mice models were established by tail vein injection of STZ (120 mg·kg). Diabetic mice were randomly divided into 5 groups:EPP high dose group

EPP middle dose group

EPP low dose group

model control group

and metformin(10

5

2.5 g·kg-1)group; another 10 healthy mice were considered as normal control group. After the mice were treated with corresponding drugs for 14 days

their fasting blood glucose (FBG)

the activity of superoxide dismutase (SOD)

glutathione peroxidase (GSH-Px) and malonaldehyde (MDA) levels in serum and liver tissues

as well as lipid metabolism were determined(P<0.05). The pathological changes of pancreas tissues were observed through HE staining. Result: As compared with the model control group

EPP could significantly decrease the blood glucose in STZ-induced diabetic mice and decrease MDA content

but significantly increase the levels of SOD and GSH-Px in serum and liver tissues; reduce the levels of cholesterol (TC

triglyceride (TG)

and low density lipoprotein (LDLC) in serum; increase the level of high density lipoprotein (HDLC). In addition

there was an improvement on pathological changes of pancreas in EPP groups. Conclusion: EPP can significantly reduce fasting blood glucose level in diabetic mice induced by STZ

improve the ability of anti-oxidation and lipid metabolism.