To sort out and summarize the relevant literature on the protection mechanism of traditional Chinese medicine(TCM) active ingredients with the neuroprotective effects. TCM active ingredients

nervous system disease

neuroprotective effects were used as the keywords to search for the relevant literature on internal and abroad studies of neuroprotective mechanism in recent years

and then the analysis was conducted. The results showed that TCM active ingredients could suppress the neurotoxicity(against the nerve damage of Amyloid β -peptide and excitatory amino acids

improve the acetylcholine protection)

the levels of inflammation (reduce the level of interleukin-6 and tumor necrosis factor-alpha and gamma interferon)and oxidative stress damage(increase the activity of Superoxide dismutase

catalase and glutathione peroxidase

lower the level of malondialdehyde)

inhibit the cellular proliferation and apoptosis(increase the apoptosis protein expression of Bcl-2

decrease the apoptosis protein expression of Bax)

promote angiogenesis(raise angiotensin 1 and the expression of specific tyrosine kinase receptor Tie-2) and nerve growth repair(promote the secretion of vascular endothelial growth factor and chemokines cell matrix derived factor-1) that the mechanisms had neuroprotective effects. This research through the summary and analysis that explore new research ideas and the selection of drugs for nervous system disease of the nerve protective effect to offer new drug development and clinical treatment.