益智仁盐炙前后分别组成缩泉丸的缩尿部位指纹图谱比较

李梦琪; 吴珊珊; 龚晓猛; 刘斯琪; 胡昌江

doi:10.13422/j.cnki.syfjx.2017040016

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益智仁盐炙前后分别组成缩泉丸的缩尿部位指纹图谱比较

药剂与炮制 | 更新时间：2024-01-04

- 益智仁盐炙前后分别组成缩泉丸的缩尿部位指纹图谱比较
- Comparison on Fingerprint Spectrum of Urine-reducing Part of Suoquan Wan Constituted with Non-processed or Salt-processed Alpiniae Oxyphyllae Fructus Fruits
- 中国实验方剂学杂志 2017年23卷第4期页码：16-19
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81473353）
- DOI：10.13422/j.cnki.syfjx.2017040016
  中图分类号： R286.0
- 纸质出版日期：2017
- 稿件说明：
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李梦琪, 吴珊珊, 龚晓猛, 等. 益智仁盐炙前后分别组成缩泉丸的缩尿部位指纹图谱比较[J]. 中国实验方剂学杂志, 2017,23(4):16-19.

LI Meng-qi, WU Shan-shan, GONG Xiao-meng, et al. Comparison on Fingerprint Spectrum of Urine-reducing Part of Suoquan Wan Constituted with Non-processed or Salt-processed Alpiniae Oxyphyllae Fructus Fruits[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(4): 16-19.
李梦琪, 吴珊珊, 龚晓猛, 等. 益智仁盐炙前后分别组成缩泉丸的缩尿部位指纹图谱比较[J]. 中国实验方剂学杂志, 2017,23(4):16-19. DOI： 10.13422/j.cnki.syfjx.2017040016.

LI Meng-qi, WU Shan-shan, GONG Xiao-meng, et al. Comparison on Fingerprint Spectrum of Urine-reducing Part of Suoquan Wan Constituted with Non-processed or Salt-processed Alpiniae Oxyphyllae Fructus Fruits[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(4): 16-19. DOI： 10.13422/j.cnki.syfjx.2017040016.

摘要

目的：通过比较益智仁盐炙前后组成缩泉丸缩尿部位的指纹图谱，从物质基础上揭示益智仁盐炙后增强缩泉丸缩尿药效的原因。方法：采用HPLC，流动相乙腈-水梯度洗脱，检测波长230 nm。记录10批益智仁盐炙前后分别组成缩泉丸的石油醚部位HPLC图谱，建立相应指纹图谱，标定特征共有峰并比较其平均相对峰面积和平均相对保留时间。结果：益智仁盐炙后组成缩泉丸时，有11个共有峰平均相对面积明显增加，包括对缩尿药效贡献较大的1号，4号（teuhetenone A），5号（7-表-香科酮），7号色谱峰，增加率分别为123.08%，90.91%，53.33%，43.75%。结论：对缩尿作用贡献较大的4个成分含量的明显增加极有可能与缩泉丸缩尿作用的增强紧密相关，此外其他7个成分含量也有明显增加。

Abstract

Objective: A comparison was made between fingerprint spectrum of urine-reducing part of Suoquan Wan constituted with non-processed and salt-processed Alpiniae Oxyphyllae Fructus fruits to discuss the chemical composition changes after salt-processing that enhance the urine-reducing effect. Method: HPLC was used for analysis with mobile phase of acetonitrile-water for gradient elution and detection wavelength at 230 nm.HPLC spectra of 10 batches Suoquan Wan constituted with non-processed and salt-processed Alpiniae Oxyphyllae Fructus fruits were recorded.Establishing the fingerprint spectra

32 peaks marked on each fingerprint spectrum had been compared. Result: The average relative area of 11 common peaks increased after salt-processing of Alpiniae Oxyphyllae Fructus fruits.Chromatographic peaks of No.1

No.4 (teuhetenone A)

No.5 (7-epi-teucrenone B) and No.7 were the major contribution to urine-reducing effect

which increased 123.08%

90.91%

53.33% and 43.75%

respectively. Conclusion: The change of those 4 components maybe closely related to the enhancement of urine-reducing effect of Suoquan Wan

and the change of other 7 components may be synergistic to it.

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