Objective: To study the effective hemostatic components of Loropetalum chinense.Method: With blood coagulation/bleeding time in mice as the primary outcome

the different extract parts (water

30%

60%

80%

and 95% ethanol extracts) were tested for hemostatic activity. The compounds were isolated and purified by various chromatographic methods such as silica gel

ODS

Sephadex LH-20.Their structures were identified according to the physical and chemical properties and spectral data.Result: The results showed that 60% ethanol extracts had the shortest blood coagulation/bleeding time

with strongest anticoagulant effect. Nine compounds were isolated from 60% ethanol extracts and identified as tiliroside (1)

3-O-coumaroylquinic acid(2)

kaempferol-3-O-β-galactopyranosyl-(1→6)-β-D-glucopyranoside(3)

kaempferol-3-O-β-galactopyranoside (4)

5-O-coumaroylquinic acid methyl ester(5)

5-O-coumaroylquinic acid(6)

3

5-O-diocaffeoylquinic acid(7)

4

5-O-diocaffeoylquinic acid(8)

and 3

4-O-diocaffeoylquinic acid(9). All of the compounds except 1 and 4 were isolated from the plant for the first time.Conclusion: The 60%ethanol extracts of L.chinense have strong anticoagulant effect

and phenolic acids act as the main effective hemostatic component.