Objective: To investigate the effect of Wutou Chishizhi Tang on tumor necrosis factor-α (TNF-α)

B-type natriuretic peptide (BNP) and homocysteine (Hcy) levels in serum of patients with Senile Ischemic Cardiomyopathy and heart failure.Method: The 94 patients with senile ischemic cardiomyopathy and heart failure were selected randomly divided into 2 groups. 47 cases in control group were treated with basic treatment

and 47 cases in treatment group were treated with Wutou Chishizhi Tang based on the treatment in control group. Ventricular remodeling and cardiac function

serum

quality of life

clinical efficacy and adverse reactions were compared after the treatment.Result: The effective rate in control group (74.47%) was lower than that in treatment group (91.49%)

with significant difference (P<0.05). As compared with those before treatment

the left ventricular remodeling and cardiac function

serology

quality of life were changed in both groups

the left ventricular end-diastolic diameter (LVEDD)

left ventricular end systolic diameter (LVESD) in treatment group were lower than those in control group

while the left ventricular ejection fraction (LVEF) and output per minute (CO) indexes were higher than those in control group

and the levels of serum BNP

Troponin I (cTnI)

high-sensitivity C-reactive protein (hs-CRP)

TNF-α and Hcy levels were lower than those in control group after treatment (P<0.05)

in addition

the improvement on life quality in treatment group was superior to that in control group after treatment (P<0.05)

with no serious adverse reactions in both groups during treatment.Conclusion: Wutou Chishizhi Tang has clear efficacy in the treatment of Senile Ischemic Cardiomyopathy and heart failure

as it can reduce the levels of serum TNF-α

BNP and Hcy levels

and improve the quality of life.