Objective: To investigate the efficacy material basis and the compatibility mechanism of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma.Method: All the chemical components related to the two traditional Chinese herbs from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) were searched. The oral bioavailability (OB)≥50% and drug likeness (DL)≥0.18 were used as the screening conditions for molecular compounds. The potential targets related to candidate compounds were found through the TCMSP

and then the drug-target interaction network as well as target-disease interaction network were constructed.Result: The 43 candidateactive molecules

98 corresponding targets and 224 related diseases were obtained through screening according to OB and DL conditions. The top three compounds were arenaringenin (48)

formononetin (41) and shinpterocarpin (36). The top three target proteins were PTGS2 (32)

PPAR-γ (21) and ERS1 (18). Related diseases of higher degree values were non-specific cancer

inflammation

pain

breast cancer and Alzheimer's disease and so on.Conclusion: The results of the study preliminarily verified the basic pharmacological effects and related mechanisms of Platycodonis Radix-Glycyrrhizae Radix et Rhizoma

and laid a good foundation for further study on the mechanism of action.