Objective: To investigate the clinical efficacy of Shennao Fuyuan decoction in treatment of ischemic stroke andobserve its effect on hemorheology. Method: According to the diagnostic criteria and inclusion criteria

96 patients were divided into experimental group and control group with random number table. Patients in control group received conventional western medicine treatment

and patients in experimental group received Shennao Fuyuan decoction on the basis of treatment in control group. Chinese stroke scale(CSS) scores

activities of daily living(ADL) scores

traditional Chinese medicine(TCM) symptom scale scores

clinical efficacy and hemorheology indexes were observed before treatment

2 weeks and 4 weeks after treatment. Result: After treatment for 2 and 4 weeks

CSS scores

TCM symptom scale scores and hemorheology indexes in experimental group were obviously better than those in control group (P<0.01). After treatment for 2 weeks

ADL scores in treatment group were increased and significantly higher than those in control group(P<0.05)

and were extremely significantly higher than control group after treatment for 4 weeks (P<0.01). Clinical efficacy in experimental group was significantly better than that in control group after treatment(P<0.01)

and there were no statistical differences in safety indexes between the parameters before and after treatment. Conclusion: Shennao Fuyuan decoction can significantly improve the neurological function

the ability of daily living and clinical efficacy

reduce blood viscosity

and enhance their blood fluidity with high safety in patients with ischemic stroke.