Objective: To observe the effect of method of Supplementing Qi

Resolving Phlegm and Promoting Blood Circulation on glucose and lipid metabolism and obestatin in obesity type 2 diabetes mellitus

and investigate its action mechanism. Method: The 86 cases of overweight/obese patients with type 2 diabetes were randomly divided into treatment group and control group

each consisting of 43 cases. Patients in treatment group received traditional Chinese medicine (supplementing Qi

resolving phlegm and activating blood circulation)+basic therapy

and patients in control group received placebo+basic therapy. Both before and after treatment

the fasting blood glucose

postprandial 2 h plasma glucose

fastinginsulin

glycosylated hemoglobin

blood lipids

obestatin

safety indexes (three routine tests

liver and kidney function) were detected; the insulin resistance indexes (HOMA-IR)were calculated

and changes in symptoms

signs and drug adverse reactions were observed in detail. Result: The curative effect of traditional Chinese medicine in treatment group was better than that in control group after treatment(P<0.05)

and it can significantly improve the shortness of breath and fatigue/lazy words

drying mouth and polydipsia

limbs numbness or tingling

and other symptoms. After treatment

the body mass index

2 h postprandial blood glucose

glycosylated hemoglobin

and insulin resistance index in treatment group were lower than those in control group(P<0.05)

while the level of obestatin was higher than that in control group (P<0.05); the levels of cholesterol and low density lipoprotein in treatment group were significantly lower than those in control group (P<0.01)

while the level of high density lipoprotein was significantly higher than that in control group(P<0.01); there were no statistically significant differences in fasting blood glucose and triglyceride between two groups after the treatment. Conclusion: The method of Supplementing Qi

Resolving Phlegm and Promoting Blood Circulation can improve glucose and lipid metabolism disorder

insulin resistance and obestatin level in treatment group

which may be one of the active ways for Chinese herbal compound of supplementing Qi

resolving phlegm and activating blood circulation.