Objective: To observe the clinical efficacy of Duhuo Jisheng Tang for wind-cold-damp retention type arthritis

and investigate its effects onsynovial fluid inflammatory factors

oxidative stress and adipokines. Method: The 124 patients diagnosed of wind-cold-damp retention type arthritis in Dongguan Hospital of Traditional Chinese Medicine were selected and randomly divided into control group(62 cases) and observation group (62 cases).Patients in control group received conventional therapy

and patients in observation group also received Duhuo Jisheng Tang based on treatment in control group. Clinical symptom scores

synovial fluid indexes

and adipokines in both groups were observed and recorded; the clinical efficacy and complications were compared between two groups after treatment. Result: The effective rate in control group was lower than that in observation group (P<0.05). As compared with the levels before treatment

Visual analogue scale(VAS) and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scores were decreased. Lyshom scores were increased; tumor necrosis factor-α(TNF-α)

interleukin-6(IL-6) and interleukine-1β(IL-1β) in synovial fluid were decreased; nitric oxide(NO)

malondialdehyde (MDA) levels in synovial fluid were decreased; superoxide dismutase(SOD) and adiponectin(APN) levels were increased. Leptin and visfatin levels were decreased after treatment in both groups

all with significant difference (P<0.05).As compared with the control group

VAS and WOMAC scale scores were lower in observation group after treatment

Lyshom score was higher; synovial fluid TNF-α

IL-6 and IL-1β levels were lower; NO and MDA levels were lower. SOD level was higher. APN level was higher

and the levels of leptin and visfatin were lower

all with significant difference(P<0.05). Conclusion: Duhuo Jisheng Tang is very effective for wind-cold-dampretention type arthritis

and its mechanism may be associated with reducing the levels of synovial fluid inflammatory factors and oxidative stress.