Objective: To analyze and summarize composition principles of the gynecological Zhengjia prescriptions in ancient medical books by using the method of data mining

in order to provide reference for clinical treatment. Method: The information of gynecological Zhengjia prescriptions collected in the book of Traditional Chinese Medical Classics was retrieved. The composition principles were analyzed using revised mutual information

complex system entropy cluster and unsupervised hierarchical clustering in the Traditional Chinese Medicine Inheritance Support System after data entry. Result: A total of 108 prescriptions were included

involving 188 herbs

including 36 highly used herbs with the use frequency of more than 8 times

47 commonly used two-herb combinations

14 three-herb combinations

four core combinations after evolution and 2 new prescriptions. Conclusion: The frequently used herbs in ancient gynecological Zhengjia prescriptions mostly have the effects of blood-enriching

blood circulation promotion

blood-breaking

Yang-warming

Qi regulating and purgation. The core prescriptions are Siwutang and modified Guizhi Fuling Wan.