Objective: To establish quality control methods for standard decoction of Codonopsis Radix and evaluate its stability and main influencing factors. Method: Standard decoction of Codonopsis Radix was prepared

its quality control method containing the determination of lobetyolin and UPLC fingerprint was established.The main common peaks in fingerprint were identified to clarify the main chemical constituents in the standard decoction and evaluate the stability of process by calculating the parameters

such as dry extract rate

transfer rate of index components and pH of the standard decoction. Result: The concentration of lobetyolin in the standard decoction was 0.02%

the similarities of its fingerprints were >0.9;there were 12 major common peaks in the fingerprint.Dry extract rate of standard decoction of Codonopsis Radix was 45.4%

the transfer rate of lobetyolin was 58.1%. Conclusion: Methods for evaluating the quality of standard decoction of Codonopsis Radix is presented

and thickness of decoction pieces of Codonopsis Radix is the main factor affecting dry extract rate of the standard decoction.