藏族成药二十五味珍珠丸矿物元素的溯源分析及质量控制

戴达勇; 赵光跃; 贾详亮; 余涛; 王慧春; 海平; 韩晓萍; 李莉; 魏玉海

doi:10.13422/j.cnki.syfjx.2017070091

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藏族成药二十五味珍珠丸矿物元素的溯源分析及质量控制

化学与分析 | 更新时间：2024-01-04

- 藏族成药二十五味珍珠丸矿物元素的溯源分析及质量控制
- Quality Control of Tibetan Medicine Ershiwuwei Zhenzhu Wan Through Tracing Source of Its Mineral Elements
- 中国实验方剂学杂志 2017年23卷第7期页码：91-96
- 作者机构：
- 作者简介：
- 基金信息：
  
  青海省（应用）基础研究计划项目（2013-Z-761）
- DOI：10.13422/j.cnki.syfjx.2017070091
  中图分类号： R29
- 纸质出版日期：2017
- 稿件说明：
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戴达勇, 赵光跃, 贾详亮, 等. 藏族成药二十五味珍珠丸矿物元素的溯源分析及质量控制[J]. 中国实验方剂学杂志, 2017,23(7):91-96.

DAI Da-yong, ZHAO Guang-yue, JIA Xiang-liang, et al. Quality Control of Tibetan Medicine Ershiwuwei Zhenzhu Wan Through Tracing Source of Its Mineral Elements[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(7): 91-96.
戴达勇, 赵光跃, 贾详亮, 等. 藏族成药二十五味珍珠丸矿物元素的溯源分析及质量控制[J]. 中国实验方剂学杂志, 2017,23(7):91-96. DOI： 10.13422/j.cnki.syfjx.2017070091.

DAI Da-yong, ZHAO Guang-yue, JIA Xiang-liang, et al. Quality Control of Tibetan Medicine Ershiwuwei Zhenzhu Wan Through Tracing Source of Its Mineral Elements[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(7): 91-96. DOI： 10.13422/j.cnki.syfjx.2017070091.

摘要

目的：建立一种二十五味珍珠丸质量控制方法。方法：采用波长色散X射线荧光光谱仪（WD-XRF）进行定性分析，采用电感耦合等离子体发射光谱仪（ICP-AES）测定4种二十五味珍珠丸及27味处方药材的Al，Ca，Fe，K，Mg，Na，根据处方组成计算该藏族成药的矿物元素在各药材中的分布进行溯源分析。结果：二十五味珍珠丸的矿物元素主要来源于珍珠、珍珠母、金礞石、石灰华、螃蟹、牛黄、香旱芹、冬葵果、麝香等药材，各药材互相配合，相辅相成。Ca质量分数为（6.64±0.03）%，能充分反映该藏族成药的主要处方药材（珍珠和珍珠母），可以作为控制二十五味珍珠丸质量的指标。Ca回归方程为Y=6.30X-1.02（r=0.999 9），线性范围为12.5~5 000 μg；平均回收率为98.1%，RSD 1.7%。结论：通过溯源矿物元素，利用其含量可控制二十五味珍珠丸的质量，确保用药有效性，为藏族成药的质量控制提供新的研究方法。

Abstract

Objective: To establish a method for quality control of the Ershiwuwei Zhenzhu Wan. Method: Qualitative analysis was conducted by wavelength dispersive X ray fluorescence spectrometer (WD-XRF)

and inductively coupled plasma-optical emission spectrometer (ICP-OES) was used to determine the contents of Al

Na in the 4 types of Ershiwuwei Zhenzhu Wan and 27 kinds of prescription materials. Then the source of the mineral elements was traced from Tibetan materials according to the prescription compositions. Result: Mineral elements were mainly derived from pearl

nacre mother of pearl

lapis micae aureus

travertine

crab

calculus bovis

ajowan

cluster mallow fruit

musk and other materials. All the medicinal materials complemented and were compatible with each other. Calcium content was (6.64±0.03)%

which could fully reflect the main effective components in Tibetan medicine and could be used as an index for controlling the quality of Ershiwuwei Zhenzhu Wan.The regression equation of calcium was Y=6.30X-1.02 (r=0.999 9)

and its linear range was 12.5-5 000 μg

with an average recovery rate of 98.1%(RSD of 1.7%). Conclusion: The method could be applied for the quality control of the Ershiwuwei Zhenzhu Wan to ensure its effectiveness

providing a new research method for the quality control of Tibetan medicine.

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