Objective: To discuss the clinical efficacy of Compound Zhenzhu Anchuang Tablets Combined with modified Diandao powder in treating adolescent facial acne with spleen-stomach damp-heat syndrome

and its effect on facial skin. Method: One hundred and sixty-four patients were randomly divided into control group (81 cases) and observation group (83 cases) by random number table. Both groups got grading treatment according guidance

grade I:adapalene gel for external use

2 times/day

grade II and Ⅲ:added benzoyl peroxide gel

2 times/day

grade Ⅲ:added doxycycline hydrochloride tablets

100 mg/time

2 times/day. Patients in observation group took compound Zhenzhu Anchuang tablets

4 tablets/day

3 times/day. In addition to the therapy of control group

the control group took modified Diandao powder mask

1 time/day for 15 day

which later changed to 1 time for every two days. The courses of treatment were 8 weeks. And both groups got guidance of health education during the treatment. Before and after treatment

the numbers of facial acne

papules and pustules were recorded. Water content of cuticle

sebum secretion and pH were detected by VISIA skin detecting instrument. Degree of erythema and chromatosis were evaluated. And quality of life before and after treatment was evaluated by specific quality of life scale. Result: After treatment

the total effect rate in observation group was 93.98%

which was higher than 82.72% in control group

with statistically significant difference (χ2=5.074

P<0.05). After treatment

sebum secretions at middle part of brow

right cheek

right side of the nose and jaw in the two groups decreased (P<0.01)

which was more obvious in observation group (P<0.01). pH at the above four skin areas of the two group increased

particularly in observation group (P<0.01). And water content of cuticle at the above four skin areas of the two group decreased

and water content of cuticle at cheeks and nose of observation group were lower than those in control group (P<0.01). After treatment

skin lesion score in observation group was lower than that in control group (P<0.01). After treatment

scores of self-perception

emotive function

acne symptoms

social function and quality of life were increased and higher than those in control group (P<0.01). Scores of erythema and chromatosis in observation group were lower than those in control group (P<0.01). The incidence of facial irritant reaction in control group was 59.26%

which was higher than 36.14% in observation group (χ2=8.781

P<0.01). According to Ridit analysis

skin irritation reaction in observation group was lower than that in control group (P<0.05). Conclusion: In addition to dietary guidance and emotional regulations

compound Zhenzhu Anchuang tablets combined with modified Diandao powder had a good clinical effect and safety

and can promote resolution of erythema and pigmentation

improve skin texture and recovery of facial skin

and thus being worth clinical promotion.