The syndrome of Qi deficiency and blood stasis is a common syndrome of coronary heart disease in clinic. The basic treatment principle is to supplement Qi and activate blood circulation. Qi supplementing and blood circulation activating recipes

like Buyang Huanwutang

Bazhentang

Qishen Yiqi pills

are commonly used in clinic

with a good clinical curative effect. Yiqi Huoxue decoction has multiple-level

multiple-target and multiple-link advantages in treating coronary heart disease

with flexible clinical composition and small side effect. Current literature researches about treating coronary heart disease with Qi deficiency and blood stasis mainly focus on summarization of therapeutic methods

curative effect observation and prescriptions

without in-depth research and summarization of mechanisms of prescriptions. In order to clarify the targets of Yiqi Huoxue decoction

we collected relevant domestic and foreign literatures in ten years

and summarized mechanisms of Yiqi Huoxue decoction in treating coronary heart disease with Qi deficiency and blood stasis syndrome as follows:improving heart function

resisting platelet aggregation

improving blood rheology

protecting vascular endothelium

reducing inflammatory reaction

regulating blood lipid and stablizing plaque

reducing oxidative stress

increasing blood flow of coronary artery. The definition of targets of traditional Chinese medicine(TCM) is not only beneficial to guide clinical medicine

but also useful to advance the development of TCM. This paper is a systematic review of Yiqi Huoxue decoction's mechanism in treating coronary heart disease with Qi deficiency and blood stasis syndrome

and combined the characteristics of TCM with the modern pharmacological researches to elucidate the mechanism of Yiqi Huoxue decoction. This will provide some references for further studies for therapies for coronary heart disease and their mechanisms. Strengthening of researches on the mechanism of TCM prescriptions may be an important direction for future researches for Yiqi Huoxue decoction in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome.