Buzhong Yiqitang

which was created by LI Dong-yuan

has functions of tonifying middle-energizer and Qi

ascending up spleen-Qi and Yang

removing heat with sweet-warm herbs. In clinic

the decoction was used to treat spleen stomach Qi deficiency

middle-energizer sinking and other diseases related to spleen-stomach dysfunction. Modern researchers have expounded its chemical composition

pharmacological actions

mechanisms of action

quality standards and compatibility. There are a large number of papers on the compatibility discipline

but without any review summarization. This review aimed to summarize modern researches of compatibility discipline of Buzhong Yiqitang in the aspects of compatibility principle and chemical composition. The results showed the rational composition of Buzhong Yiqitang. That is to say

the lack of any single herb or herbal pair could impact the efficacy of the original prescription. In terms of the impact on chemical composition

both of the sovereign medicine and the minister medicine played a dominant role in increasing the content of hesperidin and the assistant medicine reduced the content of glycyrrhizic acid; with respect to the impact of pharmacological effectiveness

the sovereign medicine and the drug combination with tonifying Qi played the role in modulating immune

while the assistant medicines Cimicifugae Rhizoma and Buplenri Radix played a synergistic effect. Meanwhile

the drug combination with medicines for tonifying Qi and raising Yang played an irreplaceable role in modulating pathological state and metabolism of animals with insufficiency of the spleen. These results fully prove the basic theory of TCM and the theory of dosimetry. The study for compatibility principles of classical prescriptions is conducive to better interpreting the theory of the TCM and guiding clinical application and scientific researchers.