Objective: After observed long-term retention of samples

to investigate the effects of different packaging materials and storage conditions on the validity period of Rehmanniae Radix Praeparata small packaging pieces and determine their valid periods. Method: In order to determine the valid period of Rehmanniae Radix Praeparata small packaging pieces

through carrying out the 30-month long-term retention stability study

different packaging materials and storage conditions of Rehmanniae Radix Praeparata pieces were detected

including characters

moisture

contents of extract and verbascoside. Result: After 30 months of long-term stability study

as small packaging pieces

the characters

thin layer identification (TLC)

moisture

content of extract could reach the relevant provisions in the 2010 edition of Chinese Pharmacopoeia.But the content of verbascoside had large difference

and the biggest factor was the impact of packaging materials.The content of verbascoside in descending order as following:medicinal aluminum foil bag > polyethylene plastic bag > leather condensate film paper.In the vacuum cold condition

the validity of three kinds of packaging materials for Rehmanniae Radix Praeparata pieces were 30

12

6 months. Conclusion: This study can determine the package types

storage conditions and period of Rehmanniae Radix Praeparata small packaging pieces

and it also can provide research and demonstration for the packaging storage and maintenance of small package pieces of traditional Chinese medicine.