Objective: To investigate the antiviral and tumor-suppressor effect of Shufeng Jiedu capsules on Balb/C nude mice with transplant infection with epstein-barr virus (EBV)-associated CNE-2Z cells. Method: One week later after being successfully transplanted with CNE-2Z cells

Balb/C nude mice were randomly divided into 6 groups

namely model group

acyclovir group

lotus antipyretic capsules group

Shufeng Jiedu capsules high

middle

low dose groups (2.2

1.1

0.55 g·kg-1·d-1)

with seven in each group. The drugs were orally administered once a day since the day of grouping for three consecutive weeks. Body weight and tumor volume were measured at the day of administration and every other day. Three weeks later

the nude mice were put to death to collect tumor tissues

spleen and thymus and calculate average

tumor growth inhibition rate

tumor volume

relative tumor proliferation rate

relative tumor volume

thymus index and spleen index. Result: Compared with the model group

Shufeng Jiedu capsules could decrease spleen index and increase thymus index. Shufeng Jiedu capsules high dose group could significantly reduce the nude mice tumor volume after 8 to 20 days (P < 0.05

P < 0.01); middle dose groups could significantly reduce the nude mice tumor volume after 8 to 14 days and 18 days (P < 0.05

P < 0.01); low dose groups could significantly reduce the nude mice tumor volume after 8 days and 12 days (P<0.05). Meanwhile

Shufeng Jiedu capsules showed a certain tumor growth inhibition trend in terms of the relative tumor proliferation rate. Conclusion: Shufeng Jiedu capsules showed an inhibitory effect on with nude mice with transplant infection with EBV-associated CNE-2Z cells.