Objective: Toexplore the medication rules of traditional Chinese medicine (TCM) prescriptions for embryonic diapause

in order to provide reference for the clinical treatment of blighted ovum. Method: Based on Chinese Medical Classics(edition V)

literatures of TCM prescriptions for treating embryonic diapause were collected. Totally 52 prescriptions recorded in the TCM Inheritance Platform System were about medication rules. Result: With a high repetition rate

Bazhentang showed the highest repetition rate.Totally 84 TCMs were involved

including 29 TCM herbswith the usage frequency ≥ 3.Furthermore

the 24 groups of commonly used drug combinations involved 8 TCM herbs and 27 groups of association rules. Finally

6 core combinations and 3 new prescriptions are evolved from the database. Conclusion: In the ancient literatures

tonic medicines are the major medicine for embryonic diapause

and thehealthy movement of the spleen and stomach functiona on the normal development of the embryo was emphasized

particularly the medicines nourishing Qi to invigorate spleen

nourishing blood and Qi circulation and activating blood circulation. The new prescriptions strengthening spleen

supplementing Qi

regulating blood and resolving phlegm were developed as the main principles

which provide ideas and reference for clinical treatment.