Objective: To study the effect of Fuzheng Sanjie prescription in inhibiting non-small cell lung cancer and regulating serum vascular endothelial growth factor (VEGF) and tumor supplied group of factors (TSGF). Method: A total of 130 cases of non-small cell lung cancer patients were divided into chemotherapy group (A group

32 cases)

comprehensive group (Fuzheng Sanjie prescription+chemotherapy group

B group

48 cases) and Fuzheng Sanjie prescription group (C group

50 cases). After treatment

curative effect

recurrence and metastasis

traditional Chinese medicine(TCM) symptoms

improvement in quality of life and regulation in serum VEGF and TSGF were analyzed. Result: B group's control display rate reached 79.6%

which was significantly higher than that of A

C groups (P<0.05). After treatment

metastasis in groups A

B and C were reduced by 46.8%

75.0% and 44.0% respectively. The new metastasis rate of the Fuzheng Sanjie prescription group was significantly lower than that of the chemotherapy group (P<0.05). In the aspect of TCM symptoms

B group (79.1%) showed the most obvious improvement (P<0.05)

and significant improvement in tongue nature and fur than chemotherapy group (P<0.05). And the average levels of serum VEGF and TSGF in three groups were higher than that before treatment. After treatment

the serum VEGF level of C group and B group were significantly decreased (P < 0.05

P < 0.01). The average level of TSGF in three groups slightly decreased after treatment (P<0.05). Conclusion: Fuzheng Sanjie prescription can reduce the side effects of chemotherapy

improve clinical symptoms and quality of life

decrease the levels of serum VEGF and TSGF

and reduce the occurrence of tumor metastasis.