Objective: To investigate the effect of Quyu Huatan decoction on ovary polycystic change

endocrine and metabolism in patients with polycystic ovary syndrome

and explore its action mechanism. Method: The 92 patients who met the inclusion criteria in the department of endocrinology in our hospital were selected and randomly divided into 2 group

46 cases in control group and 46 cases in observation group. Patients in control group were treated with ethinylestradiol and cyproterone acetate

1 tablet a day

and patients in treatment group received Quyu Huatan decoction based on the treatment in control group. All patients were treated for 3 menstrual cycles

and then their serological index

polycystic ovarian changes

and clinical efficacy were compared after the treatment. Result: After treatment

the levels of follicle-stimulating hormone (FSH)

luteinizing hormone (LH) and testosterone (T) were decreased

levels of estradiol (E2) were increased

levels of glucose and lipid metabolism indexes were decreased; levels of visfatin (VF)

leptin (LEP) were decreased

levels of adiponectin (APN) were increased

and the number of ovarian follicles and ovarian volume were decreased in both groups (P<0.05). As compared with control group

levels of FSH

LH and T were lower

levels of E2 were higher

levels of glucose and lipid metabolism indexes were lower

levels of VF

LEP were lower

levels of APN were higher

and the number of ovarian follicles and ovarian volume were lower in treatment group after treatment (P<0.05). The effective rate in control group (73.91%) was significantly lower than that in observation group (91.31%) (P<0.05). Conclusion: Quyu Huatan decoction had clear clinical efficacy in the treatment of polycystic ovary syndrome

and it can improve ovary polycystic changes

endocrine and metabolic function.