Objective: In order to improve the stability and solubility of quercetin

quercetin solid dispersion was prepared with the combination of polyvinyl pyrrolidone (PVP) and precipitated calcium carbonate (PCC) as carriers. Method: The quercetin solid dispersion was prepared by solvent evaporation method.The microscopic structure and physicochemical properties of the solid dispersion were analyzed by scanning electron microscopy (SEM) and differential scanning calorimetry (DSC)

in vitro dissolution behavior and stability of the solid dispersion were also investigated by small cup method and stability test

respectively. Result: Quercetin in the solid dispersion was amorphous form in the carriers.The cumulative release rate of quercetin in the solid dispersion [drug-matrix (1:3)

PVP-PCC (2:1)]was >90% at 15 min.The stability of quercetin solid dispersion was not affected by light

high humidity and high temperature. Conclusion: Quercetin solid dispersion

prepared by combining PVP with PCC as a hybrid carrier

has an immediate release effect;and it can significantly increase the dissolution behavior of quercetin with good stability.