Objective: To establish a quantitative analysis for the determination of the six components in Congrong Zonggan capsule based on multi-components with a single-marker (QAMS) method and ultra-high performance liquid chromatography (UPLC)

and compare with the standard curve method

in order to evaluate the adaptation and application of QAMS method in the quality control of Congrong Zonggan capsule. Method: Chrlorogenic acid and acteoside were used as the internal reference substances. The relative correlation factors (RCF) of caffeic acid with chrlorogenic acid

as well as tubuloside A

isoacteoside and echinacoside with acteoside were calculated and established. At the same time

the durability of each RCF was investigated. The results were compared with those obtained by the standard curve method

in order to verify the accuracy and feasibility of the method. Result: Within the linear ranges

the RCF values of chlorogenic acid with caffeic acid was 0.538

and that of acteoside with tubuloside A

isoacteoside and echinacoside were 1.346

1.266 and 1.135

respectively. The durability of each RCF was good. The two methods showed no significant difference in assay results for the 10 batches of samples. The obtained RCF was credible. Conclusion: The QAMS method is feasible and credible

and could be used to determine the multiple components in Congrong Zonggan capsule.