Objective: To explore the effect of Yifei Xuanfei decoction on inflammatory cytokines of chronic obstructive pulmonary disease at acute exacerbation stage based on the thought of strengthening Yang. Method: Patients with chronic obstructive pulmonary disease at acute exacerbation stage who were hospitalized from January 2015 to June 2016 were randomly divided into control group and treatment group

with 60 patients in each group. Control group received routine therapy for anti-infection

eliminating phlegm and relieving asthma. In addition to the therapy

treatment group was also given Yifei Xuanfei decoction. Before and after the treatment

forced vital capacity (FVC)

forced expiratory volume in 1 second (FEV1%)

FEV1/FVC

hypersensitive C reactive protein (hs-CRP)

equivalent Series Resistance (ESR)

interleukin-6 (IL-6)

interleukin-8 (IL-8)

interleukin-17 (IL-17)

tumor necrosis factor-alpha (TNF-α)

syndrome score of traditional Chinese medicine(TCM) and the recurrence rate were detected. Result: The efficiency of two groups had no significant difference. Before and after the treatment

two groups showed significant reductions in FEV1 and FEV1/FVC(P<0.05)

with no statistically significant difference. Before and after the treatment

two groups showed significant reductions in hs-CRP

ESR

IL-6

IL-8

IL-17

TNF-alpha and comparison of TCM syndrome score (P<0.05). The difference between groups was statistically significant (P<0.05). Conclusion: Yifei Xuanfei decoction could down-regulate inflammatory factors

improve disease symptom and reduce the recurrence rate

with a considerable clinical efficacy and long-term efficacy.