Objective: Clinical curative effect is closely related to the specifications and quality of Chinese medicine decoction pieces.Chemical fingerprint methods and DNA molecular identification technology were used to evaluate the quality of precise powder decoction pieces (PPDP) of Notoginseng Radix et Rhizoma by comparing with the traditional commercial slices. Method: Different specifications of PPDP of Notoginseng Radix et Rhizoma were prepared

their dry extract yields were in contrast with those of commercial slices;three batches of commercial slices were collected

the content uniformity

fingerprint and similarity evaluation before and after the mixing and pulverization were studied by HPLC-DAD and DNA sequence alignment. Result: Dry extract yield of PPDP of Notoginseng Radix et Rhizoma were remarkablely higher than that of the traditional commercial slices.Dissolution rates of notoginsenoside R1

ginsenoside Rg1 and Rb1 in PPDP were higher than those of traditional commercial slices.RSDs of inter-assay dissolution of the three components of commercial slices were 13.1%

32.7% and 24.5%

respectively

which could be reduced to 3.6%

2.6% and 3.5% after mixing and preparing into PPDP.After comminution

the similarity of fingerprints was improved

14 peaks were identified and their peak areas were improved. Conclusion: PPDP and traditional commercial slices of Notoginseng Radix et Rhizoma share consistent properties

while PPDP can apparently improve dry extract yield

dissolution rate and quality uniformity.