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纸质出版日期:2017
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刘超, 陈光, 高嘉良, 等. 中成药治疗眩晕用药规律分析[J]. 中国实验方剂学杂志, 2017,23(11):202-207.
LIU Chao, CHEN Guang, GAO Jia-liang, et al. Composition Principles of Chinese Patent Medicine for Treating Vertigo[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(11): 202-207.
刘超, 陈光, 高嘉良, 等. 中成药治疗眩晕用药规律分析[J]. 中国实验方剂学杂志, 2017,23(11):202-207. DOI: 10.13422/j.cnki.syfjx.2017110202.
LIU Chao, CHEN Guang, GAO Jia-liang, et al. Composition Principles of Chinese Patent Medicine for Treating Vertigo[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(11): 202-207. DOI: 10.13422/j.cnki.syfjx.2017110202.
目的:分析2015年版《中国药典》一部及《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药成方制剂》)中治疗眩晕中成药的组方规律。方法:采用中医传承辅助平台(V2.5),提取《中国药典》和《中药成方制剂》中治疗眩晕的中成药,录入中成药信息,构建数据库,分析中成药治疗眩晕的证候类型、常用药物、组方规律及新方。结果:通过对329种治疗眩晕中成药的分析发现,眩晕主要分为实证型眩晕和虚证型眩晕2种。①实证型眩晕共涉及147种中成药,证型以肝阳上亢和瘀血阻络为主,病机包括了风、火、痰和瘀,药物以清热药、活血药和平肝潜阳药为主,药物组合为黄芩、黄连、黄柏、栀子,半夏、陈皮、茯苓、甘草、白术和天麻、川芎、丹参、葛根相配伍,得出了针对实证病机的5个新方:祛风方、熄风方、泻火方、化痰方和活血方。②虚证型眩晕共涉及182种中成药,证型主要是气血两虚和肝肾亏虚,药物以补肾药、补血药和补气药为主,药物组合为熟地黄、山药、茯苓、枸杞子、五味子,人参、麦冬、五味子、茯苓和当归、黄芪、白术、山药相配伍,得出了针对虚证病机的3个新方:补肾方、滋肝肾方和益气血方。结论:眩晕的发生病机多端,包括风火痰瘀虚,治疗中应注重风火痰瘀虚的不同侧重,审证求因,做到虚实兼顾,标本同治,从而提高临床疗效。
Objective: To analyze the composition principles of Chinese patent medicine for treating vertigo in Chinese Pharmacopeia (2015 edition
volume I) and the People's Republic of Chinese Ministry of Public Health-Chinese Patent Preparations (Chinese Patent Preparations for short). Method: Through Traditional Chinese Medicine Inheritance Support System (TCMISS
V2.5)
Chinese patent medicines for treating vertigo set forth in Chinese Pharmacopeia and Chinese Patent Preparation were selected
their information was entered to build a database. The frequently used syndromes and drugs
combination principles and new Chinese prescriptions for vertigo were analyzed. Result: By analyzing 329 Chinese patent medicines for treating vertigo
vertigo could be classified into excess syndrome and deficiency syndrome. ① The vertigo of excess syndrome totally involved 147 Chinese patent medicines
the main syndromes were liver-Yang hyperactivity and obstruction of collaterals by blood stasis; The pathogenesis included wind
fire
phlegm and blood stasis. The drugs were dominated by heat-clearing drugs
blood-activating drugs and calming-liver and suppressing liver-yang drugs. The main drug combinations were Scutellariae Radix
Coptidis Rhizoma
Phellodendri Chinensis Cortex
Gardeniae Fructus; Pinellia Rhizoma
Citri Reticulatae Pericarpium
Poria
Glycyrrhizae Radix et Rhizoma
Atractylodis Macrocephalae Rhizoma and Gastrodiae Rhizoma
Chuanxiong Rhizoma
Salviae Miltiorrhizae Radix et Rhizoma
Puerariae Radix. Five new prescriptions for excess syndrome were obtained: wind-dispelling prescription
wind-calming prescription
fire-purging prescription
phlegm-eliminating prescription and blood-activating prescription. ②The vertigo of deficiency syndrome totally involved 182 Chinese patent medicines
the main syndromes were deficiency of Qi and blood and deficiency of liver and kidney
the drugs were based on kidney-reinforcing drugs
blood-tonifying drugs and Qi-invigorating drugs
the main combinations were Rehmanniae Radix Praeparata,Dioscoreae Rhizoma,Poria,Lycii Fructus,Schisandrae Chinensis Fructus;Ginseng Radix et Rhizoma,Ophiopogonis Radix,Schisandrae Chinensis Fructus,Poria and Angelicae Sinensis Radix,Astragali Radix,Atractylodis Macrocephalae Rhizoma,Dioscoreae Rhizoma,and got 3 new prescriptions according to deficiency syndrome 's pathogenesis: reinforcing kidney prescription
nourishing liver and kidney prescription
reinforcing Qi and blood prescription. Conclusion: The pathogenesis of vertigo was complex
including wind
fire
phlegm
blood stasis and deficiency. We should pay attention to all of them in the treatment
determine etiologic factors based on differentiation
give consideration to both excess and deficiency
and treat both the symptoms and the causes of disease
in order to improve the clinical efficacy.
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