Objective: To dig up the medication rules used by famous doctors in Lingnan bone injury. Method: The database of Lingnan bone injury prescriptions were established through collecting and analyzing famous doctors' works

manuscripts

papers and other literature. Frequency analysis

Latent Dirichlet Allocation (LDA) thematic model and association rules were used to analyze their medication rules. Result: The literature of lingnan bone injury involved 802 prescriptions and 811 kinds of traditional Chinese medicine (TCM) herbs. The warm drugs were used most

accounting for 28.3%. The drugs categories were dominated by dissipating blood stasis drugs

tonifying deficiency drugs

Qi-regulating drugs

heat-clearing drugs

removing wind-dampness drugs

and interior-warming drugs. Five core prescriptions were obtained from the LDA thematic model

and the through association rules analysis

a total of 21 herbal pairs and herbal group association rules. The core herbs included Angelicae Sinensis Radix

Chuanxiong Rhizoma

Paeoniae Radix Alba

Paeoniae Radix Rubar and so on. Conclusion: The famous doctors of Lingnan bone injury emphasized the treatment of activating blood and resolving stasis. On this basis

the drugs showed obvious early

middle and late stages of drugs use for bone injury: in early stage

clearing heat and detoxicating

or emphasizing hemostasis

or opening orifice and waking up；in middle stage

both attacking and tonifying

or both tonifying liver and kidney；in late stage

mostly tonifying (tonifying Qi

blood and spleen)

combined with activating Qi

blood

and nourishing liver and kidney. On this basis

the medication also reflected the importance of invigorating spleen and eliminating dampness in characteristic treatment in Lingnan bone injury.