Objective: To compare the quality control indexes and chemical constituents of crude and processed products of Achyranthis Bidentatae Radix. Method: According to standard in the 2015 edition of Chinese Pharmacopoeia

the quality control indexes and chemical constituents of crude and processed products of Achyranthis Bidentatae Radix were investigated

such as water content

total ash content and alchohol soluble extract content.UPLC-Q-TOF/MS was established to compare the contents of major constituents in crude and processed products of Achyranthis Bidentatae Radix.Moreover

the linearity

precision

stability

repeatability and recoveries of the approach were well validated. Result: The water content

total ash content and alchohol soluble extract content of crude and processed products of Achyranthis Bidentatae Radix all met the requirements of the 2015 edition of Chinese Pharmacopoeia.Ten major constituents were tentatively deduced.Compared with these of the crude products

the contents of benzyl glucoside

benzyl glucoside isomer

polypodine B

β-ecdysterone and ginsenoside Ro in the wine processed products were significantly increased.The contents of zingibroside R1

bidentatoside Ⅰ and chikusetsusaponin Ⅳ were significantly decreased.For the salt processed products

the contents of benzyl glucoside

benzyl glucoside isomer

achyranthesterone A

polypodine B

β-ecdysterone and inokosterone were significantly increased.The contents of zingibroside R1

ginsenoside Ro

bidentatoside Ⅰ and chikusetsusaponin Ⅳ were significantly decreased. Conclusion: The contents of phenolic glycosides and steroidal saponins are significantly increased

while the content of triterpenoid saponins is significantly decreased

which may be degraded under heating condition.