Objective: To compare anti-inflammatory and antipyretic effect of Sophorae Flavescentis Radix pieces between integrated production process and traditional processing method. Method: Anti-inflammatory and detumescence effects of water extracts of two Sophorae Flavescentis Radix pieces was observed by xylene-induced ear edema in mice.Antipyretic effect of water extracts of two kinds of Sophorae Flavescentis Radix pieces was compared in febrile rats induced by yeast. Result: Compared with the blank group

water extracts of two kinds of Sophorae Flavescentis Radix pieces could reduce the ear edema of mice

but the anti-inflammatory and detumescence effects of the integrated processed pieces was more significant

the inhibition rates of its each dose group were more than 40%.Antipyretic experiment showed that all the three doses of integrated processed pieces could decrease the body temperature of fever rats for 4 hours

and the antipyretic effect was superior to the traditional processed pieces.The contents of five main active ingredients in integrated processed pieces

such as sophocarpine

matrine

N-oxysophocarpine

sophoridine and oxymatrine

were higher than these in traditional processed pieces

their total amount was about 1.3 times to the traditional processed pieces. Conclusion: There has good similarity in the main effect of anti-inflammatory and antipyretic between integrated processed and traditional processed pieces

the integration processing method will standardize production process from the source

and it can shorten the production cycle under the premise of ensuring the quality of pieces.