WU Yu-fu, LIU Xiao-hong, GUO Wei-cheng, et al. Effect of Buyang Huanwu Tang on Cerebral Vascular Reserve Function in Patients with Qi Deficiency and Blood Stasis Type Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(12): 162-167.
WU Yu-fu, LIU Xiao-hong, GUO Wei-cheng, et al. Effect of Buyang Huanwu Tang on Cerebral Vascular Reserve Function in Patients with Qi Deficiency and Blood Stasis Type Cerebral Infarction[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(12): 162-167. DOI: 10.13422/j.cnki.syfjx.2017120162.
Objective: To explore the effect of Buyang Huanwu Tang on cerebral vascular reserve function in patients with Qi deficiency and blood stasis type cerebral infarction by using transcranial Doppler (TCD) combined with breath holding test
and to observe the clinical efficacy and neurological deficit scores in two groups. Method: The 150 patients with Qi deficiency and blood stasis type cerebral infarction were randomly divided into 2 groups:the treatment group of 78 cases and the control group of 72 cases. Patients in both groups received standardized western medicine treatment:aspirin enteric-coated tablets
100 mg/times
1 time/day; or Clopidogrel Bisulfate tablets
75 mg/times
1 time/day; medicines for reducing intracranial pressure
brain protective drugs
statin lipid-lowering therapy or rehabilitation therapy was given to regulate blood pressure and blood sugar according to actual conditions. Based on the western medicine treatment
patients in control group added Sanqi Tongshu capsules
0.2 g/times
3 times/day
but the patients in treatment group added Buyang Huanwu Tang on the basis of western medicine treatment
180 mL/time
2 times/day. Before and after treatment
TCD combined with breath holding test was used to determine the cerebral vascular reserve (CVR)
breath holding index (BMI) and mean velocity (Vm) rate; in addition
the clinical efficacy and NIHSS scores were observed in both groups. Result: The total effective rate was 91% in treatment group
better than 76.4% in control group (P<0.05). Day 7 and day 14 after treatment
the NIHSS scores in treatment group were significantly reduced (P<0.05)
and they were lower than those in control group (P<0.05). On day 14 after treatment
the levels of CVR
BMI and Vm were increased in treatment group (P<0.05)
and the level of CVR in treatment group was higher than that in conrol group (P<0.05). Conclusion: On the basis of routine treatment of Western medicine
Buyang Huanwu Tang can improve the cerebral vascular reserve function in patients with Qi deficiency and blood stasis type cerebral infarction
so as to improve neurological function and improve clinical efficacy.