Objective: To observe the effect of Fuzheng Jianer paste on non acute phase of recurrent upper respiratory tract infection (RRTI) in children

and investigate its effect on levels of T lymphocyte subsets

immunoglobulin and Th1/Th2 cell factor. Method: One hundred and sixty patients with RRTI at non acute phase were randomly divided into control group and observation group by random number table. Patients in control group received pidotimod oral solution

400 mg/time

1 time/day. Zinc gluconate oral solution

5 mL/time

2 times/day for 3-6 years old

and 7.5 mL/time

2 times/day for 7-12 years old; and vitamin A and C were appropriately supplemented. In observation group

the patients received Fuzheng Jianer paste

5 mL/time

3 times/day for morning fasting for 3-6 years old

10 mL/time for 7-12 years old

2 times/day. The course of treatment was 24 weeks for both groups. An follow-up after the treatment course was conducted for 24 weeks. Attack times of respiratory tract infection

duration time and disease type were recorded during the 48 weeks. Levels of serum immunoglobulin (IgA

IgG and IgM)

T lymphocyte subsets (CD3+

CD4+

CD8+

CD4+/CD8+)

interleukin-2 (IL-2)

interferon-γ (IFN-γ)

interleukin-4 (IL-4) and interleukin-5 (IL-5) were detected. Result: Clinical curative effect was 52.7% in observation group

higher than 32.88% in control group (χ2=5.898

P<0.05). Total effective rate of traditional Chinese medicine (TCM) symptoms was 94.59% in observation group

higher than 78.08% in control group (χ2=8.524

P<0.01). During 48 weeks

the average numbers of attacks (recurrent upper respiratory tract infection

bronchitis

pneumonia) in observation group was less than those in control group

and the average course of disease was also shorter than that in control group (P<0.01). The levels of IgG

IgA and IgM as well as CD3+

CD4+ and CD4+/CD8+ and IL-2 and IFN-γ in observation group were higher than those in control group after treatment (P<0.01)

and the levels of CD8+

IL-4 and IL-5 were lower than those in control group (P<0.01). Conclusion: Fuzheng Jianer paste can improve immunity

regulate balance of Th1/Th2

so it can reduce occurrence frequency of respiratory tract infection

shorten attack course

improve cure RRTI rate in the treatment of RRTI with high safety and reliability.