均匀设计 偏最小二乘回归结合因子分析探索大黄 厚朴组分配伍的规律

陈银芳; 余日跃; 业康; 聂斌; 彭红; 徐国良

doi:10.13422/j.cnki.syfjx.2017130008

您当前的位置：

首页 >

文章列表页 >

均匀设计偏最小二乘回归结合因子分析探索大黄厚朴组分配伍的规律

药剂与炮制 | 更新时间：2024-01-04

- 均匀设计偏最小二乘回归结合因子分析探索大黄厚朴组分配伍的规律
- Exploration of Compatibility Regularity of Components in Rhei Radix et Rhizoma and Magnoliae Officinalis Cortex by Uniform Design-partial Least Squares Regression Combined with Factor Analysis
- 中国实验方剂学杂志 2017年23卷第13期页码：8-12
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81160424）;国家重点基础研究发展计划（973计划）项目（2010CB530603）;江西省中医药科技计划项目（2015A247）
- DOI：10.13422/j.cnki.syfjx.2017130008
  中图分类号： R289.1
- 纸质出版日期：2017
- 稿件说明：
移动端阅览
陈银芳, 余日跃, 业康, 等. 均匀设计偏最小二乘回归结合因子分析探索大黄厚朴组分配伍的规律[J]. 中国实验方剂学杂志, 2017,23(13):8-12.

CHEN Yin-fang, YU Ri-yue, YE Kang, et al. Exploration of Compatibility Regularity of Components in Rhei Radix et Rhizoma and Magnoliae Officinalis Cortex by Uniform Design-partial Least Squares Regression Combined with Factor Analysis[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(13): 8-12.
陈银芳, 余日跃, 业康, 等. 均匀设计偏最小二乘回归结合因子分析探索大黄厚朴组分配伍的规律[J]. 中国实验方剂学杂志, 2017,23(13):8-12. DOI： 10.13422/j.cnki.syfjx.2017130008.

CHEN Yin-fang, YU Ri-yue, YE Kang, et al. Exploration of Compatibility Regularity of Components in Rhei Radix et Rhizoma and Magnoliae Officinalis Cortex by Uniform Design-partial Least Squares Regression Combined with Factor Analysis[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(13): 8-12. DOI： 10.13422/j.cnki.syfjx.2017130008.

摘要

目的：采用均匀设计和偏最小二乘回归结合因子分析考察大黄-厚朴中大黄素、芦荟大黄素、厚朴酚及和厚朴酚4种成分的组方配伍规律。方法：健康雄性SD大鼠160只，随机分为8个组，依次为假手术组、模型组及四因素六水平均匀设计的6个配方组。胰胆管内逆行注射3.5% 牛磺胆酸钠法建立急性胰腺炎大鼠模型。术后6，24 h分别检测血清淀粉酶（AMS），胰脂肪酶（PL），白细胞介素-6（IL-6），IL-10，肿瘤坏死因子-α（TNF-α）的含量变化。偏最小二乘回归分析探索各因素对各药效指标的影响规律，因子分析抽提多项指标中的公共因子。结果：各组分对急性胰腺炎病症的贡献度排序为厚朴酚>和厚朴酚>大黄素>芦荟大黄素。因子分析抽提出隐藏在多项指标后的公共因子为胰腺损伤因子（AMS，IL-6和TNF-α）和炎症因子（PL和IL-10）。结论：采用均匀试验设计、偏最小二乘回归结合因子分析可有效地分析组分配伍中多因素与多效应成分之间的关联规律，为临床病症的治疗提供方-症更为对应的组分配方。

Abstract

Objective: To investigate the compatibility regularity of components (emodin

aloe-emodin

magnolol and honokiol) in Rhei Radix et Rhizoma and Magnoliae Officinalis Cortex by uniform design and partial least squares regression combined with factor analysis. Method: SD rats were randomly divided into 8 groups

including sham-operated group

model group and six compatibility groups.The rat model of acute pancreatitis was established by the retrograde injection of 3.5% sodium taurocholate.Abdominal aortic blood was drawn at 6 hour and 24 hour for determination of serum amylase(AMS)

pancreatic lipase(PL)

interleukin-6(IL-6)

IL-10 and tumor necrosis factor-α(TNF-α).The partial least squares regression was adopted to explore the influence law of factors on efficacy index

and factor analysis was used to extract the public factors in indexes. Result: The influence degree of each component on acute pancreatitis was in the order of magnolol>honokiol>emodin>aloe-emodin.Factor analysis extracted two public factors

such as pancreatic injury factors(AMS

IL-6 and TNF-α) and inflammatory factors(PL and IL-10). Conclusion: This method

uniform design-partial least squares regression combined with factor analysis

can effectively clarify the correlation and regularity between many factors and many components

which can provide more suitable effect formulas for clinical symptoms.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

基于相对质量常数的姜厚朴饮片等级评价

高效液相色谱法测定藿香正气丸(大蜜丸)中厚朴酚、和厚朴酚含量

香砂养胃丸（浓缩丸）中厚朴酚与和厚朴酚的含量测定

HPLC法测定参香养胃胶囊中橙皮苷、丁香酚、和厚朴酚、厚朴酚的含量

半夏厚朴汤君臣佐使配伍对和厚朴酚与厚朴酚含量的影响