Objective: To observe the effect of Gandouling tablet combined with Sodium Dimercaptopropane Sulfonate on the levels of propylene glycol and superoxide dismutase in serum of patients with phlegm and blood stasis type Wilson's disease (WD)

and investigate its mechanism. Method: The 120 WD patients in The First Affiliated Hospital of Anhui University of Chinese Medicine were randomly divided into control group and treatment group

with 60 cases in each group. Patients in control group received Sodium Dimercaptopropane Sulfonate routine treatment

and patients in treatment group added Gandouling tablets based on the treatment in control group for a total of 4 treatment courses. Before and after treatment

the serum propylene glycol (MDA)

superoxide dismutase (SOD)

24 h urine copper and other indicators such as neurological function scores were observed. Result: In the both groups after treatment

MDA content was decreased

SOD activity was increased (P<0.05)

and the effect in treatment group was significantly better than that in control group (P<0.05); neurological function scores were decreased in both groups (P<0.05)

and the effect in treatment group was significantly better than that in control group (P<0.01); 24 h urine copper was improved in both groups

and the effect in treatment group was more significant (P<0.01); the decoppering effect in treatment group was better than that in control group (P<0.05); liver function indexes were decreased in both groups (P<0.05)

and the effect in treatment group was significantly better than that in control group (P<0.01). However

ceruloplasmin and copper oxidase levels did not change much after treatment in both groups. The adverse reactions results showed that there were less side effects in treatment group. Conclusion: The combination of traditional Chinese and Western medicine treatment can significantly reduce the content of serum MDA in WD patients

increase the activity of SOD

strengthen the decoppering effect

improve clinical symptoms

and to a certain extent

it can delay the progress of the disease and relieve pain for the patients. Moreover

it had less adverse reactions with high safety

so it should be widely used in clinical application.