Objective: To discuss the efficacy of modified Wuzi Yanzongwan for female infertility caused by luteal phase defect (LPD) and investigate its effect on hormone levels and endometrial receptivity. Method: One hundred and thirty patients were randomly divided into control group (65 cases) and observation group (65 cases) by random number table. Patients in control group took Dydrogesterone tablets from the day of ovulation detected by vaginal B-ultrasound

20 mg/day for continuous 10 days. If not pregnant

Dydrogesterone tablets were taken continuously at the next menstrual cycle. If pregnant

Dydrogesterone tablets can be taken at the early pregnancy stage and their dose shall be adjusted according to progesterone levels. Patients in observation group added modified Wuzi Yanzongwan

1 dose/day. Pregnant women in both groups took vitamin E capsules

0.1 g/time

3 times/day. The treatment course was 3 menstrual cycles for both groups

and the follow-up period was also 3 menstrual cycles after treatment. The pregnancy was recorded for a total of 6 months (treatment and follow-up)

and the live fetus rate was observed in follow-up. Basal body temperature (BBT) was detected

and the scores of high-temperature phase (HPS) of luteal basal body temperature were graded. Levels of follicle stimulating hormone (FSH)

luteinizing hormone (LH)

estradiol (E2) and progesterone were detected. Dominant follicle conditions

and endometrial thickness were recorded by colorful B-ultrasound. Endometrial spiral arteries pulsatility index (PI)

resistance index (RI) and endometrial thickness were measured and recorded. Scores of Salle and kidney essence deficiency syndrome were graded. The above indexes were evaluated both before and after treatment. Result: The total effective rate for the disease was 93.65% in observation group

higher than 77.42% in control group (χ2=6.678

P<0.01). Clinical pregnancy rate was 52.38% in observation group

higher than 32.26% in control group (χ2=5.181

P<0.05) after treatment

but there was no statistically significant difference in live fetus rate between two groups. After treatment

levels of FSH

LH

E2 and P and scores of HPS and Salle were higher than those in control group (P<0.01). Diameter of dominant follicle was shorter than that in control group (P<0.01). And score of kidney essence deficiency syndrome was lower than that in control group (P<0.01). Endometrial thickening was less than that in control group (P<0.01). PI and RI were lower than those in control group (P<0.01). Ratio of type A endometrium was larger than that in control group (P<0.01). There were no adverse reactions and serious adverse events during treatment. Conclusion: Modified Wuzi Yanzongwan can regulate HPOA axis

improve luteal function

ameliorate hormone and endometrial receptivity

reduce scores of kidney essence deficiency to improve pregnancy rate. Its clinical efficacy is superior to that of western medicine.