Objective: To explore the pharmacological mechanism of Curcumae Rhizoma through a series of system pharmacology methods. Method: Active ingredients of Curcumae Rhizoma were obtained through traditional Chinese Medicine Systems Pharma cology(TCMSP) database. The target proteins of Curcumae Rhizoma were obtained by PharmMapper Server

the gene name of the targets were obtained by UniProt database

and the main diseases related to Curcumae Rhizoma were obtained by the database of CTD. Then

the target proteins interaction network of Curcumae Rhizoma was built using software Cytoscape. Next

gene ontology (GO) analysis on protein groups and enrichment analysis on action pathways were performed by DAVID tool. Result: Text mining results showed that relevant diseases of Curcumae Rhizoma included neoplastic diseases

neurological diseases and metabolic diseases. GO analysis indicated that Curcumae Rhizoma played a biological role mainly through steroid hormone-mediated signaling pathways

RNA polymerase Ⅱ promoter transcription

negative regulation of process

peptidyl tyrosine phosphorylation

protein autophosphorylation

retinoic acid receptor signaling pathways and positive regulation of transcription from RNA polymerase Ⅱ promoter. The signaling pathway enrichment results showed that main action proteins of Curcumae Rhizoma were related to the pathways of cancer

PPAR signal pathway

proteoglycan in cancer

non-small cell carcinoma and PI3K-Akt signaling pathway. Conclusion: Curcumae Rhizoma may exert its biological functions primarily by regulating multiple pathways

such as cancer pathway

PPARP signaling pathway

PI3K-Akt signaling pathway. The pharmacological action of a drug can be rapidly and comprehensively analyzed through system pharmacology.