Objective: To observe the therapy effect of Jiaotaiwan adding and subtraction prescription on the function of heart and kidney of patients with advanced cardiorenal syndrome (CRS). Method: The 60 cases patients with CRS were randomly divided into treatment group and control group. The patients in treatment group were treated with Jiaotaiwan adding and subtraction decoction based on routine western medicine. The treatment course was 14 days in both groups

and then the main traditional Chinese medicine(TCM) symptoms such as asthma

edema

and oliguria

as well as heart and kidney functions of patients were observed and the curative effect was evaluated in both groups. Result: The total symptom score of patients in treatment group was decreased and had significant difference as compared with control group (P<0.05); the improvement in TCM syndrome in treatment group was better than that of control group (P<0.05). New York Heart Association (NYHA) cardiac functional grading was improved after treatment in both groups (P<0.01). The level of NT-probrain natriuretic peptide (NT-proBNP) in treatment group was obviously decreased after treatment (P<0.01)

and that of the decrease was more obvious in treatment group as compared with that in control group (P<0.01). The level of blood urea nitrogen (BUN) in treatment group was lower than that of control group (P<0.05). The level of cystatin-C (Cys-C) was decreased in both groups after treatment (P<0.05

P<0.01)

and the decrease was more obvious in treatment group as compared with that in control group (P<0.05). Conclusion: Jiaotaiwan adding and subtraction decoction can improve the functional deterioration of heart and kidney for patients in the advanced stage of cardiorenal syndrome.