Objective: To observe the clinical efficacy of Bupiwei Xieyinghuo Shengyang Tang combined with mesalazine in the treatment of ulcerative colitis

and their effect on inflammatory cytokines. Method: A total of 195 patients with ulcerative colitis were selected and divided with the random number table method into control group 1

control group 2 and treatment group

with 65 cases in each group. The control group 1 was orally given mesalazin enteric-coated table

1 g/time

tid. In addition to oral administration with mesalazin enteric-coated table

the control group 2 was also orally given Chenliji Bupi Yichang pill

6 g/time

tid. The treatment group was treated with Bupiwei Xieyinghuo Shengyang Tang

100 mL/time

tid

in addition to oral administration with mesalazin enteric-coated table. Before and after treatment

symptoms

colorectal mucosa score changes

high sensitivity C-reaction protein (hs-CRP)

interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were observed

and statistics was made for the clinical efficacy. Result: The treatment group showed reductions in symptoms (abdominal pain

diarrhea

pus and blood stool)

colon mucosa score

cytokines (hs-CRP

IL-6

TNF-alpha) compared with control group 1 and control group 2 (P<0.05). The total effective rates of treatment group

control group 1 and control group 2 were 93.85%

78.46%

81.54%

respectively

indicating treatment group was superior to control group 1 and control group 2 in the clinical efficacy (P<0.05). Conclusion: Bupiwei Xieyinghuo Shengyang Tang combined with mesalazine can effectively alleviate clinical symptoms of ulcerative colitis and colorectal mucosa

improve the level of cytokines

and provide an effective prescription for clinical explorations for traditional Chinese medicine for the treatment of ulcerative colitis

and is worth further promotion and application.