喜炎平联合双水平正压无创通气治疗痰热壅肺型AECOPD合并呼吸衰竭与肺炎的疗效及对PCT，sTREM-1和生活质量的影响

郝文东; 王国芳; 张彩莲

doi:10.13422/j.cnki.syfjx.2017140193

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喜炎平联合双水平正压无创通气治疗痰热壅肺型AECOPD合并呼吸衰竭与肺炎的疗效及对PCT，sTREM-1和生活质量的影响

临床 | 更新时间：2024-01-04

- 喜炎平联合双水平正压无创通气治疗痰热壅肺型AECOPD合并呼吸衰竭与肺炎的疗效及对PCT，sTREM-1和生活质量的影响
- Efficacy of Xiyanping Combined with BiPAP Non-invasive Ventilation in Treatment of AECOPD with Syndrome of Phlegm-heat Obstructing Lung Complicated with Respiratory Failure and Pneumonia and Effects on PCT, sTREM-1 and Quality of Life
- 中国实验方剂学杂志 2017年23卷第14期页码：193-197
- 作者机构：
- 作者简介：
- 基金信息：
  
  延安市科学技术发展计划项目（2015KW-09）
- DOI：10.13422/j.cnki.syfjx.2017140193
  中图分类号： R563
- 纸质出版日期：2017
- 稿件说明：
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郝文东, 王国芳, 张彩莲. 喜炎平联合双水平正压无创通气治疗痰热壅肺型AECOPD合并呼吸衰竭与肺炎的疗效及对PCT，sTREM-1和生活质量的影响[J]. 中国实验方剂学杂志, 2017,23(14):193-197.

HAO Wen-dong, WANG Guo-fang, ZHANG Cai-lian. Efficacy of Xiyanping Combined with BiPAP Non-invasive Ventilation in Treatment of AECOPD with Syndrome of Phlegm-heat Obstructing Lung Complicated with Respiratory Failure and Pneumonia and Effects on PCT, sTREM-1 and Quality of Life[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 193-197.
郝文东, 王国芳, 张彩莲. 喜炎平联合双水平正压无创通气治疗痰热壅肺型AECOPD合并呼吸衰竭与肺炎的疗效及对PCT，sTREM-1和生活质量的影响[J]. 中国实验方剂学杂志, 2017,23(14):193-197. DOI： 10.13422/j.cnki.syfjx.2017140193.

HAO Wen-dong, WANG Guo-fang, ZHANG Cai-lian. Efficacy of Xiyanping Combined with BiPAP Non-invasive Ventilation in Treatment of AECOPD with Syndrome of Phlegm-heat Obstructing Lung Complicated with Respiratory Failure and Pneumonia and Effects on PCT, sTREM-1 and Quality of Life[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(14): 193-197. DOI： 10.13422/j.cnki.syfjx.2017140193.

摘要

目的：观察喜炎平注射液联合双水平正压无创通气（BiPAP）治疗痰热壅肺型慢性阻塞性肺疾病急性加重期（AECOPD）合并呼吸衰竭与肺炎的疗效，及对降钙素原（PCT），可溶性髓样细胞触发受体-1（sTREM-1）和生活质量的影响。方法：将150例AECOPD合并呼吸衰竭与肺炎患者按照随机数字表法分为观察组和对照组，各75例。2组均予以吸氧，抗感染，平喘，BiPAP呼吸机辅助通气等常规治疗，观察组在上述治疗基础之上，给予喜炎平注射液治疗，连续治疗10 d。结果：本研究共入选153例患者，1例自行退出，1例不能按照本方案治疗，1例因出现肺性脑病，转入重症监护室（ICU）行有创机械通气治疗，故符合本方案者150例。观察组、对照组总有效率分别为84%，69%，观察组优于对照组（P<0.05）。两组肺功能[1 s用力呼气容积（FEV1），呼气峰值流速（PEF）]，血气分析（pH，PaCO2，PaO2）和慢性阻塞性肺疾病评估测试（CAT）评分均较治疗前改善，观察组改善优于对照组（P<0.05）。治疗后，两组炎症相关因子sTREM-1，PCT水平下降（P<0.05）。组间比较，治疗后观察组sTREM-1，PCT血清水平低于对照组（P<0.05）。结论：BiPAP呼吸机辅助通气联合喜炎平注射液治疗痰热壅肺型AECOPD合并呼吸衰竭与肺炎疗效较好，能迅速缓解临床症状，改善呼吸衰竭，提高生活质量和运动耐力，降低血清炎症因子水平。

Abstract

Objective: To observe the clinical efficacy of Xiyanping injection combined with bi-level positive airway pressure (BiPAP) in treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients with respiratory failure and pneumonia and the effect on procalcitonin (PCT)

soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and quality of life. Method: A total of 150 AECOPD patients with respiratory failure and pneumonia were randomly divided into observation group and control group

with 75 cases in each group. The control group was given conventional therapies

such as oxygen uptake

anti-infection

antiasthmatics

BiPAP noninvasive breathing machine. The observation group was given Xiyanping injection

in addition to the conventional therapies. The treatment lasted for continuously 10 days. Result: After 10 days of treatment

among the 153 cases

one case exited

one case could not follow this therapeutic regimen

and one case suffered from pulmonary encephalopathy and transferred to intensive care unit(ICU) for invasive mechanical ventilation. Therefore

150 eligible cases were left. The total effective rate of the observation group (84%) was significantly higher than that of control group (69%)

with statistically significant differences (P<0.05). After 10 days of treatment in both groups

pulmonary function (FEV1 and PEF)

blood gas analysis (pH

PaCO2

PaO2) and score of CAT were improved. And observation group was superior to control group (P<0.05). After 10 days of treatment

two groups showed decreases in inflammatory indicators of sTREM-1

PCT levels (P<0.05). After treatment

the observation group showed lower sTREM-1

PCT serum levels than control group (P<0.05). Conclusion: Xiyanping injection combined with BiPAP non-invasive treathing machine can achieve a good clinical efficacy in treatment of AECOPD with respiratory failure and pneumonia

and can effectively relieve clinical symptoms

alliviate respiratory failure

improve the quality of life and exercise tolerance and reduce serum inflammatory factors.

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