Objective: To discuss the clinical efficacy of early intervention of Xiaoshuan Tongluo granules on ischemic stroke (wind phlegm stagnation syndrome) and observe its effect on inflammatory factors and neurological factors. Method: One hundred and sixty patients were randomly divided into control group and observation group by random number table. The patients in both groups received comprehensive medical treatment measures and rehabilitation measures by referring to the guide. Patients in control group got acupuncture and Chinese medicine rehabilitation measures; based on the treatment in control group

the patients in observation group also received Xiaoshuan Tongluo granules

12 g/time

3 times/day. The treatment course was 4 weeks in both groups. Before treatment and at day 7

day 14 and day 28 after treatment

scores of neurological deficits in the US national institutes of health (NIHSS) were graded. Activities of daily living were evaluated by functional independence rating scale (FIM). Functional activities of the limbs were evaluated by Fugl-Meyer functional scale (FMA). Disability or death was evaluated by modified Rankin scale (mRS). Before and after treatment

levels of soluble adhesion molecules (SICAM-1)

high-sensitivity C-reactive protein (hs-CRP)

interleukin-6 (IL-6)

tumor necrosis factor-α(TNF-α)

S100-β protein (S100-β)

angiopoietin-1 (ANG-1) and endothelin-1(ET-1)were detected

and safety evaluation was conducted. Result: The total effective rate for the disease was 89.47% in observation group

higher than 77.03% in control group (χ2=4.182

P<0.05). By analysis of variance for repeated measures

scores of NIHSS were decreased after treatment in both groups (Fcontrol=7.026

Fobservation=7.683

P<0.05)

and at the 14th and 28th days after treatment

NIHSS score in observation group was lower than that in control group (P<0.05 or P<0.01). Scores of FIM (Upper limbs

lower limbs) and Fugl-Meyer and the total score in observation group were higher than those in control group after treatment (P<0.01). And the scores of symptoms

psychological dimensions and total scores in PRO scale in observation group were lower than those in control group (P<0.01). In rank sum test

cases of disability or death were less than those in control group after treatment (P<0.01). And the levels of SICAM-1

hs-CRP

IL-6

TNF-α and S100-β

ANG-1 and endothelin-1 in observation group were lower than those in control group (P<0.01). Conclusion: In the comprehensive program

Xiaoshuan Tongluo granules can ameliorate nerve defect function

decrease degree of disability

improve patients' clinical efficacy

inhibit expression levels of SICAM-1

hs-CRP

IL-6 and TNF-α

regulate levels of S100-β

ANG-1 and ET-1

relieve inflammation

protect nerve cells

and promote neurological rehabilitation.