Objective: To analyze the effect of Danshenyin on gastrointestinal inhibition and immune index of patients with bladder cancer after chemotherapy and its action mechanism. Method: A total of 140 patients with bladder cancer were included in the study. All of the patients received chemotherapy. Among them

70 patients were selected to take Danshenyin during chemotherapy (observation group)

while the remaining patients were control group. Proportion of gastrointestinal inhibition

cellular immunity

humoral immunity

natural killer (NK) and serum-related factor level were compared before and after chemotherapy. Result: Within 24 hours after chemotherapy

the proportion of Ⅲ-Ⅳ of control group were higher than that of observation group (P<0.05). The proportion of level 0 of control group was lower than that of observation group (P<0.05). Within 72 hours after chemotherapy

the proportion of level 0 of observation group was still higher than that of control group

and the proportions of Ⅰ-Ⅱ and Ⅲ-Ⅳ were lower than those of the control group. After chemotherapy

CD3+

CD4+ and CD4+/CD8+ levels of two groups were lower than those before chemotherapy (P<0.05). CD8+ level was higher than that before chemotherapy (P<0.05). CD3+

CD4+ and CD4+/CD8+ levels of observation group were better than those of control group (P<0.05). After chemotherapy

immunoglobulin A (IgA) and immunoglobulin M (IgM) levels of two groups were lower than those before chemotherapy (P<0.05). After chemotherapy

NK level of two groups was lower than that before chemotherapy (P<0.05). The observation group decreased less than control group (P<0.05). Interleukin-12 (IL-12) and tumor necrosis factor-α (TNF-α) levels of the observation group were lower than those of control group (P<0.05). Conclusion: During chemotherapy

Danshenyin can effectively reduce gastrointestinal inhibition and adjust immune function.