Objective: To discuss the clinical efficacy of oral and enema treatment with modified Taohe Chengqitang on early intestinal obstruction after abdominal surgery and its effect on neurological and inflammatory factors. Method: One hundred and thirty-eight patients were randomly divided into control group and observation group by random number table

with 69 cases in each group. Patients in control group got comprehensive therapies including persistent gastrointestinal decompression

rehydration

correction of acid-base balance and water and electrolyte disorder

and anti-infection. And they got ceftazidime for injection

2 g/time

for 7 days

somatostatin for injection for continuous micro pump pumped

6 mg/24 hours

for 3 days

and methicillin neostigmine injection

2 mL/time. intramuscular injection. The observation group in control group to the basis of modified Taohe Chengqitang into stomach and enema

2 dose/day. The course of treatment was for 7 days. Times of abdominal pain relief

abdominal distension relief

bowel sounds recovery and ventilation defecation

gastric tube retention

eating

body temperature recovery and white blood cell count recovery

length of stay and surgical transit were recorded. Before and after treatment

damp heat stasis syndromes were scored. And levels of vasoactive intestinal peptide (VIP)

procalcitonin (PCT)

nitric oxide (NO)

monocyte chemoattractant protein-1 (MCP-1)

serum interleukin-6 (IL-6)

tumor necrosis factor -α (TNF-α) and C-reactive protein (CRP) were detected. Result: The total clinical effective rate of traditional Chinese medicine(TCM)in observation group was 91.31%

which was higher than 75.37% in control group (χ2=6.618

P <0.01). Time of abdominal pain relief

abdominal distension relief

bowel sounds recovery

ventilation defecation

gastric tube retention

eating

body temperature recovery and white blood cell count recovery

length of stay and surgical transit were all shorter than those in control group (P <0.01). Transfection rate in observation group was 5.8%

which was lower than 18.84% in control group (χ2=5.434

P <0.05). After treatment

levels of VIP

PCT

NO

MCP-1

IL-6

TNF-α and CRP were lower than those in control group (P <0.01). Conclusion: In addition to western medicine therapy

oral and enema treatment of modified Taohe Chengqitang can regulate nerve mediators

reduce inflammation damage

relieve intestinal obstruction

shorten the course of disease

and improve the success rate of conservative treatment for patients of early intestinal obstruction after abdominal surgery

with a better effect than pure western medicine therapy.