Objective: To discuss the clinical efficacy of Qihuang Tongluo decoction on uremia peripheral neuropathy (UPN) based on sympathetic skin reaction(SSR)

and the mechanism according to uremic toxins and levels of prophylactic factors. Method: One hundred and fifty-four patients with uremia were randomly divided into control group and observation group by random number table. Both groups' patients were given hemodialysis and blood perfusion. Patients in control group got three-dimensional B injection for intramuscular injection

2 mL/time

3 times/week

methylcobalamin tablets

0.5 mg/time

3 times/day. In addition to the therapty of control group

patients in observation group were also given Qihuang Tongluo decoction

1 dose/day. One course of treatment was three months. Before and after treatment

Latency (Lat) and peak-pesk amplitude (Amp) were detected by electromyography evoked potentiometer

and sensory nerve conduction velocity of tibial nerve

peroneal nerve and sural nerve were also detected. Before and after treatment

spleen and kidney Qi deficiency and blood stasis syndrome were scored. Before and after treatment

levels of parathyroid hormone (PTH)

β2-microglobulin (β2-MG)

leptin (LP)

homocysteine (Hcy)

tumor necrosis factor-α (TNF-α)

serum C-reactive protein (CRP)

interleukin-6 (IL-6) and interleukin-8 (IL-8) were also detected. Result: The total effect rate of traditional Chinese medicine(TCM) in observation group was 93.06%

which was higher than 74.29% in control group (χ2=9.212

P <0.01). Lat of upper and lower limbs in observation group were shorter than those in control group

and Amp of upper and lower limbs in observation group were longer than those in control group (P <0.01). After treatment

the abnormality rate of SSR in observation group was 26.39%

which was lower than 66.67% in control group before treatment (χ2=23.471

P <0.01)

and 44.29% in control group after treatment (χ2=4.983

P <0.01). After treatment

sensory nerve conduction velocity of tibial nerve

common peroneal nerve and sural nerve in observation group were all faster than those in control group (P <0.05 or P <0.01). Levels of PTH

β 2-MG

LP

Hcy

TNF-α

CRP

IL-6

IL-8 were lower than those in control group (P <0.01). Conclusion: Qihuang Tongluo decoction can improve the patient's neurological function

and promote the recovery of peripheral nerve function. Its mechanism may be related to the removal of uremic toxins and the reduction of inflammatory responses.