Objective: To investigate the efficacy and mechanism of Shenfutang. Method: The chemical components and corresponding targets related to Shenfutang were searched from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The compound-target network and the protein-protein interaction(PPI) network were established

and the GO functional enrichment analysis and the KEGG pathway enrichment analysis were made to explore the mechanism of Shenfutang. Result: The compound-target network contained 23 chemical components and 118 targets. The hub targets involved PTGS2

PTGS1

NCOA2

ADRB2.The PPI network contained 114 proteins

in which the hub proteins involved AKT

AP-1

p56.The GO functional enrichment analysis showed 236 GO entries (including 191 for biological process

20 for molecular function

25 for cellar component). The KEGG pathway enrichment analysis showed 10 pathways

involving calcium signaling pathway

neuroactive ligand-receptor interaction

apoptosis

and pathways in cancer. Conclusion: The result of the study preliminarily verifies the basic pharmacological effects and related mechanisms of Shenfutang

thus laying a solid foundation for further study on the mechanism of action.