Objective: To investigate the efficacy and safeness of Gandou decoction combined with sodium dimercaptopropane sulfonate in the treatment of Wilson's disease (WD) with damp-heat syndrome. Method: Totally 245 WD patients were collected and divided into two groups: treatment group (125 cases) and control group (120 cases). The treatment group was treated with Gandou decoction combined with sodium dimercaptopropane sulfonate

while the control group was treated with sodium dimercaptopropane sulfonate alone. Before and after treatment

global assessment scale (GAS) was used to score. The clinical and laboratory parameters were observed. Result: After 4 courses of treatment

patients in two groups showed obvious alleviations in neurological symptoms

and the score of GAS in treatment group decreased more obviously. The treatment group also showed alleviations in laboratory indexes

like asalanine aminotrans (ALT)

aspertate transaminase (AST) and 24-hour urinary

compared with control group. White blood cell were found to be unchanged in treatment group

but greatly dropped in control group. Adverse reaction was reported

with obvious differences between two groups. The commonest adverse reactions were leukocytopenia

hepatic impairment

abdominal discomfort and neurological deterioration. Conclusion: The regimen of Gandou decoction combined with sodium dimercaptopropane sulfonate is an effective and safe therapy for patients of WD with damp-heat syndrome.