Objective: To optimize main preparation technology of Shufeng Dingchuan granules.Method: Ovalbumin was used to prepare bronchial asthma model in guinea pigs.The guinea pigs were randomly divided into normal group

model group

aminophylline group

Kechuanning group

Shufeng Dingchuan granules routing 1

2

3 and 4 groups.From the 15th day

the guinea pigs were placed in the apparatus which can cause asthma.The normal group were spray with saline

the other groups sprayed with 10% ovalbumin for consecutively 7 days

2 times a day

15 min at a time.At the same time

the normal group and model group were orally given normal saline

and the other groups were orally given the drug during the middle time of 2 times induced asthma for consecutively 7 days.With the length of asthma incubation time and asthma episodes time

the contents of interleukin-4(IL-4)

tumor necrosis factor-α(TNF-α) and immunoglobulin E (IgE) as indexes to determine the main preparation technology of Shufeng Dingchuan granules.Result: Compared with the model group

routing 1

2

3 and 4 groups could reduce the contents of IL-4

TNF-α and IgE in asthma guinea pigs (P<0.01)

and delay the asthma incubation period and asthma episodes period (P<0.01).Compared with Kechuanning group

the routing 4 samples could delay the asthma incubation period and asthma episodes period (P<0.05).Compared with aminophylline group

the routing 4 samples could delay the asthma incubation period (P<0.05).Compared with the routing 2 group

the routing 4 group could delay the asthma incubation period (P<0.05).Conclusion: Routing 4 is selected as the main preparation technology of Shufeng Dingchuan granules to further optimize the technological parameters.